Abstract: This article mainly introduced the latest research progress of antimicrobial peptides (AMPs) from microorganisms in anti-tumor cells in recent years. Firstly, the types of tumor cells inhibited by AMPs from bacterial, fungal and actinomycetes sources, the characteristics of resistance of AMPs to different types of tumor cells, and the resistance effects and differences of AMPs to tumor cells were analyzed successively. Secondly, the research status of anti-tumor cell mechanism of microbial AMPs was briefly introduced, and the mechanism of inducing tumor cell apoptosis by acting on mitochondria, endoplasmic reticulum and death receptors of tumor cells was also clarified. According to this paper, the microbial source AMPs anti-tumor effect and its effect were related to the research content and the summary of the mechanism of resistance of tumor cells. It would help others more in-depth and comprehensive understanding of the microbial source AMPs new functions and point out the importance of further excavating microbial source AMPs for anti-tumor research and application of microbial source AMPs in the future to provide new ideas.

Key words: microorganism resource, antimicrobial peptide, antitumor cell activity, antitumor mechanism, Brevibacillus laterosporus